Lexatonil 3mg by Roche

 

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Chemical name is 7-Bromo-1,3-dihydro-5-(2-pyridyl)-1,4-benzodiazepin-2-one. Chemical formula is: C14H10BrN3O. Molecular weight is: 316.2. It is a white/yellow crystalline formula which is barely soluble in water and sparingly soluble in alcohol. It is a schedule IV drug in the US.

According to many psychiatric experts Bromazepam has a greater abuse potential than other benzodiazepines because of fast resorption and fast onset of action. Due to its relatively short halflife and duration of action (8 to 12 hours), withdrawal symptoms may be more severe and more frequently encountered than with long acting benzodiazepines.

Time to pleak plasma concentration after an oral dose is 30 mins to 4 hours. Half-Life is 8-30 hours. Comparative dose is 3.0 (if Diazepam is 5.0, Temazepam is 10.0 and alprazolam is 0.5) 70% of bromazepam is bound to plasma proteins

It is metabolised by the cytochrome P450 enzyme system in the liver, and thus it's metabolism may be affected my numerous other drugs including alcohol. It may interact with the effects of other CNS acting drugs such as alcohol, narcotics, hypnotics, sedative antihistamines, antipsychotics, anxiolytics/sedatives, anesthetics, antidepressants and anticonvulsants.

Clearance is reduced in the elderly and (in some studies) by coadministration of the combined oral contraceptive pill.

Therapeutic dose: 3-18 mg daily in divided doses. In exceptional circumstances, in case of hospitalized patients, maximum daily dosage of 60 mg, in divided doses, may be given.
 

Indications include

    Short-term treatment of insomnia
    Short-term treatment of anxiety or panic-attacks, if a benzodiazepine is required
    Alleviation of the symptoms of alcohol- and opioid-withdrawal, under close clincial supervision!

Contraindications include: Known hypersensitivity to benzodiazepines, myasthenia gravis, severe hepatic insufficiency, severe respiratory insufficiency, sleep apnea syndrome, or patients with known drug or alcohol dependancy issues.

It should be used with caution in those with hepatic or renal impairment.

Bromazepam is not recommended for use in patients with depressive disorders or psychosis. It should not be used concurrently with alcohol and other CNS depressant drugs.

The usual benzodiazepine side-effects apply. However Bromazepam is also reported to cause cholestatic jaundice and agranulocytosis (failure of bone marrow to produce white cells) as well as potentiating hypoglycaemia in diabetics.

 

 

Specifications
Composition	Bromazepam
Dosage	3mg/tab
Manufacturer	Roche Pakistan

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